Doing history

Diese Broschüre ist ein Ergebnis eines Lehr-Lern-Projekts, das aus einer Mittelbauinitiative am Historischen Seminar der Universität Leipzig hervorgegangen ist. In kleinen Gruppen erprobten Studierende angeleitet durch Promovierende im Rahmen eigener Forschungsprojekte historische Quellenkritik mit anderen methodischen Zugängen zu historischen Fragestellungen zu verschränken und anzuwenden. Die hier versammelten Beiträge sind Beispiele der studentischen Projekte und methodische Impulse der beteiligten Doktorand*innen

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

The IPDGC (The International Parkinson Disease Genomics Consortium) and EADB (Alzheimer Disease European DNA biobank) are listed correctly as an author to the article, however, they were incorrectly listed more than once

Doing history

Diese Broschüre ist ein Ergebnis eines Lehr-Lern-Projekts, das aus einer Mittelbauinitiative am Historischen Seminar der Universität Leipzig hervorgegangen ist. In kleinen Gruppen erprobten Studierende angeleitet durch Promovierende im Rahmen eigener Forschungsprojekte historische Quellenkritik mit anderen methodischen Zugängen zu historischen Fragestellungen zu verschränken und anzuwenden. Die hier versammelten Beiträge sind Beispiele der studentischen Projekte und methodische Impulse der beteiligten Doktorand*innen

Doing history

Diese Broschüre ist ein Ergebnis eines Lehr-Lern-Projekts, das aus einer Mittelbauinitiative am Historischen Seminar der Universität Leipzig hervorgegangen ist. In kleinen Gruppen erprobten Studierende angeleitet durch Promovierende im Rahmen eigener Forschungsprojekte historische Quellenkritik mit anderen methodischen Zugängen zu historischen Fragestellungen zu verschränken und anzuwenden. Die hier versammelten Beiträge sind Beispiele der studentischen Projekte und methodische Impulse der beteiligten Doktorand*innen

Linear Collider Physics Resource Book for Snowmass 2001, 2: Higgs and Supersymmetry Studies

This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 2 reviews the possible experiments on Higgs bosons and supersymmetric particles that can be done at a linear collider.This Resource Book reviews the physics opportunities of a next-generation e+e- linear collider and discusses options for the experimental program. Part 2 reviews the possible experiments on Higgs bosons and supersymmetric particles that can be done at a linear collider

Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus

Both obesity and being underweight have been associated with increased mortality. Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m(2) in adults and ≤ -2 standard deviations from the mean in children, is the main sign of a series of heterogeneous clinical conditions including failure to thrive, feeding and eating disorder and/or anorexia nervosa. In contrast to obesity, few genetic variants underlying these clinical conditions have been reported. We previously showed that hemizygosity of a ∼600-kilobase (kb) region on the short arm of chromosome 16 causes a highly penetrant form of obesity that is often associated with hyperphagia and intellectual disabilities. Here we show that the corresponding reciprocal duplication is associated with being underweight. We identified 138 duplication carriers (including 132 novel cases and 108 unrelated carriers) from individuals clinically referred for developmental or intellectual disabilities (DD/ID) or psychiatric disorders, or recruited from population-based cohorts. These carriers show significantly reduced postnatal weight and BMI. Half of the boys younger than five years are underweight with a probable diagnosis of failure to thrive, whereas adult duplication carriers have an 8.3-fold increased risk of being clinically underweight. We observe a trend towards increased severity in males, as well as a depletion of male carriers among non-medically ascertained cases. These features are associated with an unusually high frequency of selective and restrictive eating behaviours and a significant reduction in head circumference. Each of the observed phenotypes is the converse of one reported in carriers of deletions at this locus. The phenotypes correlate with changes in transcript levels for genes mapping within the duplication but not in flanking regions. The reciprocal impact of these 16p11.2 copy-number variants indicates that severe obesity and being underweight could have mirror aetiologies, possibly through contrasting effects on energy balance